Targeting the host response in sepsis: current approaches and future evidence

C Bode, S Weis, A Sauer, P Wendel-Garcia, S David - Critical Care, 2023 - Springer
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …

Umbilical cord mesenchymal stromal cells—from bench to bedside

S Chetty, R Yarani, G Swaminathan… - Frontiers in Cell and …, 2022 - frontiersin.org
In recent years, mesenchymal stromal cells (MSCs) have generated a lot of attention due to
their paracrine and immuno-modulatory properties. mesenchymal stromal cells derived from …

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells for COVID-19 pneumonia: a meta-analysis of randomized controlled trials

Q Liu, F Ma, Y Zhong, G Wang, L Hu, Y Zhang… - Stem Cell Research & …, 2023 - Springer
Background Elevated levels of inflammatory factors are associated with poor prognosis in
coronavirus disease-19 (COVID-19). However, mesenchymal stem cells (MSCs) have …

Repair of acute respiratory distress syndrome in COVID-19 by stromal cells (REALIST-COVID Trial): a multicenter, randomized, controlled clinical trial

EA Gorman, J Rynne, HJ Gardiner… - American Journal of …, 2023 - atsjournals.org
Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair
in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS) …

Mesenchymal stem cell therapy for COVID-19 infection

SMM Alavi-Dana, Y Gholami, M Meghdadi… - …, 2024 - Springer
COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and
caused millions of deaths in a short time. Many preclinical and clinical studies were …

Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?

GF Curley, CM O'Kane, DF McAuley… - American Journal of …, 2024 - atsjournals.org
There is considerable interest in the potential for cell-based therapies, particularly
mesenchymal stromal cells (MSCs) and their products, as a therapy for acute respiratory …

Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities

T Nagamura-Inoue, F Nagamura - Inflammation and Regeneration, 2023 - Springer
Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of
somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively …

Facing the challenges in the COVID-19 pandemic era: from standard treatments to the umbilical cord-derived mesenchymal stromal cells as a new therapeutic strategy

E Russo, S Corrao, F Di Gaudio, G Alberti, M Caprnda… - Cells, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and …

Investigational use of mesenchymal stem/stromal cells and their secretome as add-on therapy in severe respiratory virus infections: challenges and perspectives

S Mattoli, M Schmidt - Advances in Therapy, 2023 - Springer
Serious manifestations of respiratory virus infections such as influenza and coronavirus
disease 2019 (COVID-19) are associated with a dysregulated immune response and …

Drugs for the prevention and treatment of COVID-19 and its complications: An update on what we learned in the past 2 years

G Remuzzi, S Schiaffino, MG Santoro… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 Committee of the Lincei Academy has reviewed the scientific evidence
supporting the efficacy and safety of existing and new drugs/biologics for the preventing and …