Restriction of HIV-1 escape by a highly broad and potent neutralizing antibody
Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and
treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope …
treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope …
Progress toward active or passive HIV-1 vaccination
A Escolano, P Dosenovic… - Journal of Experimental …, 2017 - rupress.org
AIDS is a preventable disease. Nevertheless, according to UNAIDS, 2.1 million individuals
were infected with HIV-1 in 2015 worldwide. An effective vaccine is highly desirable. Most …
were infected with HIV-1 in 2015 worldwide. An effective vaccine is highly desirable. Most …
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells
JH Lee, L Toy, JT Kos, Y Safonova, WR Schief… - NPJ vaccines, 2021 - nature.com
A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome
the hurdle of being able to activate naive precursor B cells encoding features within their …
the hurdle of being able to activate naive precursor B cells encoding features within their …
A meta-analysis of passive immunization studies shows that serum-neutralizing antibody titer associates with protection against SHIV challenge
Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1
envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) …
envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) …
Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
Broadly neutralizing antibodies (bNAbs), able to prevent viral entry by diverse global
viruses, are a major focus of HIV vaccine design, with data from animal studies confirming …
viruses, are a major focus of HIV vaccine design, with data from animal studies confirming …
To bnAb or not to bnAb: defining broadly neutralising antibodies against HIV-1
SA Griffith, LE McCoy - Frontiers in immunology, 2021 - frontiersin.org
Since their discovery, antibodies capable of broad neutralisation have been at the forefront
of HIV-1 research and are of particular interest due to in vivo passive transfer studies …
of HIV-1 research and are of particular interest due to in vivo passive transfer studies …
Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals
C Kreer, C Lupo, MS Ercanoglu, L Gieselmann… - Nature …, 2023 - nature.com
HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent
infection. Their induction by vaccination is therefore a major goal. However, in contrast to …
infection. Their induction by vaccination is therefore a major goal. However, in contrast to …
Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells
J Dufloo, C Planchais, S Frémont, V Lorin… - Nature …, 2022 - nature.com
Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) are
promising molecules for therapeutic or prophylactic interventions. Beyond neutralization …
promising molecules for therapeutic or prophylactic interventions. Beyond neutralization …
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to …
KH Mayer, KE Seaton, Y Huang, N Grunenberg… - PLoS …, 2017 - journals.plos.org
Background VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that
is active against a broad range of HIV-1 primary isolates in vitro and protects against simian …
is active against a broad range of HIV-1 primary isolates in vitro and protects against simian …