Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2
TA Scott, A Supramaniam, A Idris, AA Cardoso… - … Therapy-Methods & …, 2022 - cell.com
SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused
significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of …
significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of …
Identification of near-pan-neutralizing antibodies against HIV-1 by deconvolution of plasma humoral responses
MM Sajadi, A Dashti, ZR Tehrani, WD Tolbert… - Cell, 2018 - cell.com
Anti-HIV-1 envelope broadly neutralizing monoclonal antibodies (bNAbs) isolated from
memory B cells may not fully represent HIV-1-neutralizing profiles measured in plasma …
memory B cells may not fully represent HIV-1-neutralizing profiles measured in plasma …
[HTML][HTML] Neutralizing monoclonal antibodies for COVID-19 treatment and prevention
JP Jaworski - biomedical journal, 2021 - Elsevier
The SARS-CoV-2 pandemic has caused unprecedented global health and economic crises.
Several vaccine approaches and repurposed drugs are currently under evaluation for safety …
Several vaccine approaches and repurposed drugs are currently under evaluation for safety …
Humanized V (D) J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors
S Luo, C Jing, AY Ye, S Kratochvil… - Proceedings of the …, 2023 - National Acad Sciences
Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V
(D) J recombination. V (D) J junctional regions encode complementarity-determining-region …
(D) J recombination. V (D) J junctional regions encode complementarity-determining-region …
[HTML][HTML] Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with> 50% breadth
X Chen, T Zhou, SD Schmidt, H Duan, C Cheng… - Immunity, 2021 - cell.com
Vaccine elicitation of broadly neutralizing antibodies (bnAbs) is a key HIV-research goal.
The VRC01 class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and …
The VRC01 class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and …
TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption
DC Hsu, A Schuetz, R Imerbsin, D Silsorn… - PLoS …, 2021 - journals.plos.org
Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb)
administration previously delayed viral rebound and induced SHIV remission. We evaluated …
administration previously delayed viral rebound and induced SHIV remission. We evaluated …
Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections
K Wagh, MS Seaman, M Zingg, T Fitzsimons… - PLoS …, 2018 - journals.plos.org
There is great interest in passive transfer of broadly neutralizing antibodies (bnAbs) and
engineered bispecific antibodies (Abs) for prevention of HIV-1 infections due to their in vitro …
engineered bispecific antibodies (Abs) for prevention of HIV-1 infections due to their in vitro …
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
D Huang, RK Abbott… - Proceedings of the …, 2020 - National Acad Sciences
Animal models of human antigen-specific B cell receptors (BCRs) generally depend on
“inferred germline” sequences, and thus their relationship to authentic naive human B cell …
“inferred germline” sequences, and thus their relationship to authentic naive human B cell …
Structural survey of broadly neutralizing antibodies targeting the HIV-1 Env trimer delineates epitope categories and characteristics of recognition
GY Chuang, J Zhou, P Acharya, R Rawi, CH Shen… - Structure, 2019 - cell.com
Over the past decade, structures have been determined for broadly neutralizing antibodies
that recognize all major exposed surfaces of the prefusion-closed HIV-1-envelope (Env) …
that recognize all major exposed surfaces of the prefusion-closed HIV-1-envelope (Env) …
Past HIV-1 medications and the current status of combined antiretroviral therapy options for HIV-1 patients
M Weichseldorfer, M Reitz, OS Latinovic - Pharmaceutics, 2021 - mdpi.com
Combined antiretroviral therapy (cART) is treatment with a combination of several
antiretroviral drugs that block multiple stages in the virus replication cycle. An estimated 60 …
antiretroviral drugs that block multiple stages in the virus replication cycle. An estimated 60 …