Innovations in HIV-1 vaccine design
LD Jones, MA Moody, AB Thompson - Clinical therapeutics, 2020 - Elsevier
Purpose The field of HIV-1 vaccinology has evolved during the last 30 years from the first
viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies …
viral vector HIV gene insert constructs to vaccination regimens using a myriad of strategies …
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
Germline-targeting (GT) protein immunogens to induce VRC01-class broadly neutralizing
antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise …
antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise …
Neutralizing antibodies for HIV-1 prevention
B Julg, DH Barouch - Current opinion in HIV and AIDS, 2019 - journals.lww.com
Encouraging results from preclinical and clinical studies support the development of bNAbs
for prevention and a number of antibodies with exceptional breadth and potency are …
for prevention and a number of antibodies with exceptional breadth and potency are …
Structural basis of broad HIV neutralization by a vaccine-induced cow antibody
Potent broadly neutralizing antibodies (bnAbs) to HIV have been very challenging to elicit by
vaccination in wild-type animals. Here, by x-ray crystallography, cryo–electron microscopy …
vaccination in wild-type animals. Here, by x-ray crystallography, cryo–electron microscopy …
[HTML][HTML] Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Remarkable progress has been achieved for prophylactic and therapeutic interventions
against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy …
against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy …
HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies
Motivation Changing the course of the human immunodeficiency virus type I (HIV-1)
pandemic is a high public health priority with approximately 39 million people currently living …
pandemic is a high public health priority with approximately 39 million people currently living …
[HTML][HTML] Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base
Summary Soluble" SOSIP"-stabilized envelope (Env) trimers are promising HIV-vaccine
immunogens. However, they induce high-titer responses against the glycan-free trimer base …
immunogens. However, they induce high-titer responses against the glycan-free trimer base …
[HTML][HTML] Indirect Mechanisms of HIV-1 Evasion from Broadly Neutralizing Antibodies In Vivo
A Herschhorn - ACS Infectious Diseases, 2022 - ACS Publications
HIV-1 continues to be a major public health concern, with approximately 37.7 million people
living with HIV-1 worldwide at the end of 2021 (www. who. int). Broadly neutralizing …
living with HIV-1 worldwide at the end of 2021 (www. who. int). Broadly neutralizing …
Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies
Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and
derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally …
derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally …
[HTML][HTML] Rational design and in vivo characterization of mRNA-encoded broadly neutralizing antibody combinations against HIV-1
E Narayanan, S Falcone, SM Elbashir, H Attarwala… - Antibodies, 2022 - mdpi.com
Monoclonal antibodies have been used successfully as recombinant protein therapy;
however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the …
however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the …