Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

[HTML][HTML] COVID-19 in immunocompromised patients: a systematic review of cancer, hematopoietic cell and solid organ transplant patients

JA Belsky, BP Tullius, MG Lamb, R Sayegh, JR Stanek… - Journal of Infection, 2021 - Elsevier
Background The clinical impact of severe coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in immunocompromised …

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

TC Theoharides, C Cholevas, K Polyzoidis… - Biofactors, 2021 - Wiley Online Library
COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome
associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome …

Role of inflammatory cytokines, growth factors and adipokines in adipogenesis and insulin resistance

L Al-Mansoori, H Al-Jaber, MS Prince, MA Elrayess - Inflammation, 2022 - Springer
Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …

The role of IL-6 and IL-6 blockade in COVID-19

N Potere, A Batticciotto, A Vecchié… - Expert review of …, 2021 - Taylor & Francis
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a
dysregulated hyperinflammatory response. Areas covered Authors review evidence on IL-6 …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

H Harb, M Benamar, PS Lai, P Contini, JW Griffith… - Immunity, 2021 - cell.com
A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

Q Liu, J Wu, X Zhang, X Li, X Wu, Y Zhao, J Ren - Cell death & disease, 2021 - nature.com
The STING pathway and its induction of autophagy initiate a potent immune defense
response upon the recognition of pathogenic DNA. However, this protective response is …

Biomimetic immunosuppressive exosomes that inhibit cytokine storms contribute to the alleviation of sepsis

Y Li, H Zhang, C Chen, K Qiao, Z Li, J Han… - Advanced …, 2022 - Wiley Online Library
Sepsis is a disease characterized by multiple organ failure caused by immune
hyperactivation and cytokine storms. Studies have shown that the incidence of sepsis in …