Potential SARS-CoV-2 main protease inhibitors
R Banerjee, L Perera, LMV Tillekeratne - Drug Discovery Today, 2021 - Elsevier
Highlights•The SARS-CoV-2 main protease is a prime drug target.•Coronavirus main
proteases share a structurally conserved substrate-binding region.•The structure and …
proteases share a structurally conserved substrate-binding region.•The structure and …
A review on drug repurposing applicable to COVID-19
S Dotolo, A Marabotti, A Facchiano… - Briefings in …, 2021 - academic.oup.com
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …
cost and in a shorter time. There are different computational drug-repurposing strategies and …
Exploration of natural compounds with anti-SARS-CoV-2 activity via inhibition of SARS-CoV-2 Mpro
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a dreaded pandemic in lack of specific …
syndrome coronavirus 2 (SARS-CoV-2), is a dreaded pandemic in lack of specific …
Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2: an in silico approach to combat COVID-19
A Swargiary, S Mahmud, MA Saleh - Journal of Biomolecular …, 2022 - Taylor & Francis
COVID-19 and its causative organism SARS-CoV2 that emerged from Wuhan city, China
have paralyzed the world. With no clinically approved drugs, the global health system is …
have paralyzed the world. With no clinically approved drugs, the global health system is …
Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules
Recent explosive growth of 'make-on-demand'chemical libraries brought unprecedented
opportunities but also significant challenges to the field of computer-aided drug discovery …
opportunities but also significant challenges to the field of computer-aided drug discovery …
Therapeutic potentials of antiviral plants used in traditional african medicine with COVID-19 in focus: a Nigerian perspective
The coronavirus disease 2019 (COVID-19) pandemic is caused by an infectious novel strain
of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening
C Gorgulla, KMP Das, KE Leigh, M Cespugli… - Iscience, 2021 - cell.com
The unparalleled global effort to combat the continuing severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising …
coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising …
GC-MS, LC-MS/MS, Docking and Molecular Dynamics Approaches to Identify Potential SARS-CoV-2 3-Chymotrypsin-Like Protease Inhibitors from Zingiber officinale …
This study aims to identify and isolate the secondary metabolites of Zingiber officinale using
GC-MS, preparative TLC, and LC-MS/MS methods, to evaluate the inhibitory potency on …
GC-MS, preparative TLC, and LC-MS/MS methods, to evaluate the inhibitory potency on …
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO
G Jiménez-Avalos, AP Vargas-Ruiz… - Scientific reports, 2021 - nature.com
SARS-CoV-2 main protease is a common target for inhibition assays due to its high
conservation among coronaviruses. Since flavonoids show antiviral activity, several in silico …
conservation among coronaviruses. Since flavonoids show antiviral activity, several in silico …
[HTML][HTML] Allosteric binding sites of the SARS-CoV-2 main protease: potential targets for broad-spectrum anti-coronavirus agents
The current pandemic caused by the COVID-19 disease has reached everywhere in the
world and has affected every aspect of our lives. As of the current data, the World Health …
world and has affected every aspect of our lives. As of the current data, the World Health …