[HTML][HTML] Proteomic features of soft tissue tumours in adolescents and young adults
Background Adolescents and young adult (AYA) patients with soft tissue tumours including
sarcomas are an underserved group with disparities in treatment outcomes. Methods To …
sarcomas are an underserved group with disparities in treatment outcomes. Methods To …
[HTML][HTML] Emerging and Biological Concepts in Pediatric High-Grade Gliomas
A Yoel, S Adjumain, Y Liang, P Daniel, R Firestein… - Cells, 2024 - mdpi.com
Primary central nervous system tumors are the most frequent solid tumors in children,
accounting for over 40% of all childhood brain tumor deaths, specifically high-grade …
accounting for over 40% of all childhood brain tumor deaths, specifically high-grade …
Statistical Testing for Protein Equivalence Identifies Core Functional Modules Conserved across 360 Cancer Cell Lines and Presents a General Approach to …
Quantitative proteomics has enhanced our capability to study protein dynamics and their
involvement in disease using various techniques, including statistical testing, to discern the …
involvement in disease using various techniques, including statistical testing, to discern the …
[HTML][HTML] Emerging target discovery and drug repurposing opportunities in chordoma
DM Freed, J Sommer, N Punturi - Frontiers in Oncology, 2022 - frontiersin.org
The development of effective and personalized treatment options for patients with rare
cancers like chordoma is hampered by numerous challenges. Biomarker-guided …
cancers like chordoma is hampered by numerous challenges. Biomarker-guided …
Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens
CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and
phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest …
phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest …
[HTML][HTML] Pediatric precision oncology:“better three hours too soon than a minute too late”
M Marshall, J Ivanovich, M Schmitt, A Helvie… - Frontiers in …, 2023 - frontiersin.org
Precision oncology is defined as the selection of an effective treatment for a cancer patient
based upon genomic profiling of the patient's tumor to identify targetable alterations. The …
based upon genomic profiling of the patient's tumor to identify targetable alterations. The …
Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma
S Stauffer, JS Roth, ER Hernandez, JT Kowalczyk… - Cancers, 2024 - mdpi.com
Simple Summary The prognosis for patients with relapsed neuroblastoma is poor, and novel
treatment options for these patients are needed. Some relapsed neuroblastoma tumors …
treatment options for these patients are needed. Some relapsed neuroblastoma tumors …
[PDF][PDF] Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma
Ewing sarcoma (EwS) is a small round blue cell tumor and is the second most frequent
pediatric bone cancer. 85% of EwS tumors express the fusion oncoprotein EWS-FLI1, the …
pediatric bone cancer. 85% of EwS tumors express the fusion oncoprotein EWS-FLI1, the …
[HTML][HTML] STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) is an aggressive, CD30+ T cell lymphoma of
children and adults. ALK fusion transcripts or mutations in the JAK-STAT pathway are …
children and adults. ALK fusion transcripts or mutations in the JAK-STAT pathway are …
[HTML][HTML] The potential of PARP as a therapeutic target across pediatric solid malignancies
KM Keller, J Koetsier, L Schild, V Amo-Addae, S Eising… - BMC cancer, 2023 - Springer
Background Pediatric cancer is the leading cause of disease-related death in children and
the need for better therapeutic options remains urgent. Due to the limited number of patients …
the need for better therapeutic options remains urgent. Due to the limited number of patients …