Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders
Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …
Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors
ZP Van Acker, M Bretou, W Annaert - Molecular neurodegeneration, 2019 - Springer
Increasing evidence supports that cellular dysregulations in the degradative routes
contribute to the initiation and progression of neurodegenerative diseases, including …
contribute to the initiation and progression of neurodegenerative diseases, including …
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
Machine learning identifies candidates for drug repurposing in Alzheimer's disease
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large
amount of time and resources with largely negative results. Repurposing drugs already …
amount of time and resources with largely negative results. Repurposing drugs already …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease
Alzheimer's disease (AD) lacks protein biomarkers reflective of its diverse underlying
pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used …
pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used …
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain
Y You, S Muraoka, MP Jedrychowski… - Journal of …, 2022 - Wiley Online Library
In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …
and are consequently involved in disease progression. We have investigated the proteomic …
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease
Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are
early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the …
early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the …