In the present work, we have reviewed data showing that triiodothyronine and its nuclear
receptors modify expression of different genes/proteins involved in cell cycle control …

The molecular genetics underlying thyroid carcinogenesis is not clear. Recent identification
of a PAX8-peroxisome proliferator-activated receptor γ (PPAR γ) fusion gene in human …

The β-catenin pathway has been conclusively demonstrated to regulate differentiation and
patterning in multiple model systems. In thyroid cancer, alterations are often seen in proteins …

Simple Summary Dysregulation of the thyroid hormone receptor beta (TRβ) is characteristic
of many solid and endocrine-related tumors. Despite a recognized role as a tumor …

Correlative data suggest that thyroid hormone receptor-β (TRβ) mutations could increase the
risk of mammary tumor development, but unequivocal evidence is still lacking. To explore …

Aberrant expression and mutations of thyroid hormone receptor genes (TRs) are closely
associated with several types of human cancers. To test the hypothesis that TRs could …

Association studies suggest that thyroid hormone receptor β (TRβ) could function as a tumor
suppressor in breast cancer development, but unequivocal evidence is still lacking. To …

BACKGROUND Some studies have suggested that there is an association between breast
carcinoma and thyroid carcinoma. Because ionizing radiation is a well known risk factor for …

Background: Previous studies showed a close association between several types of human
cancers and somatic mutations of thyroid hormone receptor β (TRβ) and reduced expression …

Abstract Thyroid hormone, 3, 3′, 5-triiodo-L-thyronine (T 3), mediates cell growth,
development and differentiation by binding to its nuclear receptors (TRs). The role of TRs in …