Thyroid hormones (TH) regulate key cellular processes, including proliferation,
differentiation, and apoptosis in virtually all human cells. Disturbances in TH pathway and …

Cyclin D1 is an oncogenic cyclin frequently over-expressed in cancer. To examine the effect
of thyroid hormone (T3) and its receptor (TR) on the transcription of cyclin D1 gene, we co …

Hypothyroidism has been associated with significantly elevated risk for hepatocellular
carcinoma (HCC), although the precise underlying mechanisms remain unknown at present …

Purpose There are a growing number of reports suggesting that the aberrant expression and
mutation of the thyroid hormone receptor β1 (TRβ1) gene is associated with the …

Thyroid cancer is considered the most common malignancy that affects the endocrine
system. Generally, thyroid cancer derives from follicular epithelial cells, and thyroid cancer is …

Thyroid hormone (TH) influences a wide variety of biological events in vertebrates. Among
them, the balance between proliferation and differentiation is crucial in TH action in normal …

While many proteins are known clients of heat shock protein 90 (Hsp90), it is unclear
whether the transcription factor, thyroid hormone receptor beta (TRb), interacts with Hsp90 to …

The thyroid hormone receptors (TRs) mediate the pleiotropic activities of the thyroid
hormone (T3) in growth, development, and differentiation and in maintaining metabolic …

Simian virus 40 (SV40) sequences were investigated in human thyroid tumors of different
histotypes, Graves' disease thyroid specimens, normal thyroid tissues, and peripheral blood …

Thyroid hormone receptor β (THRβ) is a member of the nuclear receptor superfamily of
ligand-modulated transcription factors. Upon ligand binding, THRβ sequentially recruits the …