Objective In sporadic inclusion body myositis (IBM), inflammation and accumulation of β‐
amyloid–associated molecules cause muscle fiber damage. We undertook this study to …

Alzheimer's disease (AD), the most common form of dementia, disproportionately affects
women in both prevalence and severity. This increased vulnerability to AD in women is …

Accumulation of amyloid β protein (Aβ)-containing neuritic plaques in the brain is a
neuropathological feature of Alzheimer's disease (AD). The β-site APP-cleaving enzyme 1 …

Amyloid β protein (Aβ) is the primary component of senile plaques in Alzheimer's disease
brains and its aggregate form is neurotoxic. Aβ is generated through proteolysis of β-amyloid …

The glycoprotein nicastrin (NCT) is an essential component of the γ‐secretase complex, a
high molecular weight complex which also contains the presenilin proteins, Aph‐1 and Pen …

Neuritic plaque is the pathological hallmark in A lzheimer's disease (AD). Amyloid‐β protein
(A β), the central component of neuritic plaques, is generated from amyloid‐β precursor …

The presenilin‐associated complex regulates two independent intramembranous cleavage
activities, ie γ‐secretase and ε‐secretase activity. The γ‐secretase complex requires four …

Sporadic inclusion-body myositis (s-IBM) is the most common muscle disease of older
persons. Its muscle-fiber phenotype shares several molecular similarities with Alzheimer …

Amyloid β peptide (Aβ42) is a major determinant of Alzheimer's disease (AD). In this study,
we studied a novel single-chain variable fragment (scFv), AS, generated from an antibody …

Background: Although clinical vitamin A deficiency (VAD), which is a public health problem
developing throughout the world, has been well controlled, marginal vitamin A deficiency …