Frailty is a common geriatric syndrome characterized by increased vulnerability and is
associated with adverse clinical events such as falls, hospitalization, and death. Early …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

The older population is increasing worldwide, and life expectancy is continuously rising,
predominantly thanks to medical and technological progress. Healthspan refers to the …

Aging is a natural intrinsic process associated with the loss of fibrous tissue, a slower cell
turnover, and a reduction in immune system competence. In the skin, the continuous …

Adult spinal deformity (ASD) surgery is still associated with high surgical risks. Machine
learning algorithms applied to multicenter databases have been created to predict outcomes …

Background Frailty is suggested to be associated with age-related changes in the immune
system, namely immunosenescence. Few studies have investigated the association of frailty …

The influence of nutritional factors on frailty syndrome is still poorly understood. Thus, we
aimed to confirm cross-sectional associations of diet-related blood biomarker patterns with …

Complex interrelationships may exist among different types of frailty. This study aimed to
evaluate the demographic and biological factors that influence the different types of frailty in …

The frailty index (FI) uses a deficit accumulation approach to derive a single,
comprehensive, and replicable indicator of age-related health status. Yet, many researchers …

Several biomarkers have been proposed to identify frailty, a multisystemic age-related
syndrome. However, the complex pathophysiology and the absence of a consensus on a …