The long and short non-coding RNAs modulating EZH2 signaling in cancer

S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

Progress in understanding the role of lncRNA in programmed cell death

N Jiang, X Zhang, X Gu, X Li, L Shang - Cell death discovery, 2021 - nature.com
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but not
translated into proteins. LncRNAs regulate gene expressions at multiple levels, such as …

The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

Epigenetics of aging and disease: a brief overview

C Pagiatakis, E Musolino, R Gornati… - Aging clinical and …, 2021 - Springer
Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA–target regulations in human diseases

H Zhao, X Yin, H Xu, K Liu, W Liu, L Wang… - Nucleic Acids …, 2023 - academic.oup.com
An updated LncTarD 2.0 database provides a comprehensive resource on key lncRNA–
target regulations, their influenced functions and lncRNA-mediated regulatory mechanisms …

Long noncoding RNA URB1-antisense RNA 1 (AS1) suppresses sorafenib-induced ferroptosis in hepatocellular carcinoma by driving ferritin phase separation

Y Gao, M Tong, TL Wong, KY Ng, YN Xie, Z Wang… - ACS …, 2023 - ACS Publications
Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC),
has been shown to be a potent ferroptosis inducer in HCC. However, we found that there …

An update on the multifaceted roles of STAT3 in the heart

Z Harhous, GW Booz, M Ovize, G Bidaux… - Frontiers in …, 2019 - frontiersin.org
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and
transcription factor that plays important protective roles in the heart. The protection mediated …

The roles and mechanisms of lncRNAs in liver fibrosis

Z He, D Yang, X Fan, M Zhang, Y Li, X Gu… - International journal of …, 2020 - mdpi.com
Many studies have revealed that circulating long noncoding RNAs (lncRNAs) regulate gene
and protein expression in the process of hepatic fibrosis. Liver fibrosis is a reversible wound …

Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression

L Wang, L Sun, R Liu, H Mo, Y Niu, T Chen… - Journal of Experimental …, 2021 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are widely involved in human
cancers' progression by regulating tumor cells' various malignant behaviors. MAPKAPK5 …

Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers

Y Shi, Q Wang, R Song, Y Kong, Z Zhang - EBioMedicine, 2021 - thelancet.com
Abstract Non-coding RNAs (ncRNAs), including microRNAs, circular RNAs, and long non-
coding RNAs, are important regulators of normal biological processes and their abnormal …