Frontal–subcortical circuits form the principal network, which mediate motor activity and
behavior in humans. Five parallel frontal–subcortical circuits link the specific areas of the …

While characterization of pathogenetic mechanisms underlying major depression is a
fundamental aim of neuroscience research, an equally critical clinical goal is to identify …

Treatment-resistant depression is a severely disabling disorder with no proven treatment
options once multiple medications, psychotherapy, and electroconvulsive therapy have …

OBJECTIVE: Theories of human behavior from Plato to Freud have repeatedly emphasized
links between emotion and reason, a relationship now commonly attributed to pathways …

Psychiatric comorbidities, including mood, anxiety, and psychotic disorders, are common in
epilepsy, often occurring at rates 2–3-fold or higher than in the general population without …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

Background: Treatment of major depression with antidepressants is generally associated
with a delay in onset of clinical response. Functional brain correlates of this phenomenon …

Retrieving a subset of items can cause the forgetting of other items, a phenomenon referred
to as retrieval-induced forgetting. According to some theorists, retrieval-induced forgetting is …

Backgroud Major depression is a frequent psychiatric complication among patients with
traumatic brain injury (TBI). To our knowledge, however, the clinical correlates of major …

THE relationship between pretreatment regional cerebral glucose metabolism and eventual
antidepressant drug response was measured using positron emission tomography (PET) in …