COVID-19 has caused over 1 million deaths globally, yet the cellular mechanisms
underlying severe disease remain poorly understood. By analyzing several thousand …

Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4)
to the pathogenesis of cardiovascular diseases (CVD) and type 2 diabetes (T2D) …

Background Genome-wide association studies (GWAS) have revealed numerous loci
associated with stroke. However, the underlying mechanisms at these loci in the …

Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …

In the present study, we investigated the distribution of genetic variations in IL6 and IL6R
genes, which may be employed as prognostic and pharmacogenetic biomarkers for COVID …

OBJECTIVE To identify circulating proteins influencing type 1 diabetes susceptibility using
Mendelian randomization (MR). RESEARCH DESIGN AND METHODS We used a large …

DNA methylation and blood circulating proteins have been associated with many complex
disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we …

Immune system and blood–brain barrier dysfunction are implicated in the development of
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …

With increasing age of the population, countries across the globe are facing a substantial
increase in osteoporotic fractures. Genetic association signals for fractures have been …

Cardiometabolic diseases are frequently polygenic in architecture, comprising a large
number of risk alleles with small effects spread across the genome,–. Polygenic scores …