Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

[HTML][HTML] Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

M Låg, J Øvrevik, M Refsnes, JA Holme - Respiratory research, 2020 - Springer
Epidemiological studies have found strong associations between air pollution and
respiratory effects including development and/or exacerbation of asthma and chronic …

Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial

F Liu, Y Zhu, J Zhang, Y Li, Z Peng - BMJ open, 2020 - bmjopen.bmj.com
Introduction The rapid worldwide spread of COVID-19 has caused a global health crisis. To
date, symptomatic supportive care has been the most common treatment. It has been …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Immunological mechanisms of the antitumor effects of supplemental oxygenation

SM Hatfield, J Kjaergaard, D Lukashev… - Science translational …, 2015 - science.org
Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich
tumor microenvironments (TMEs) by A2A adenosine receptors. This may limit further …

[HTML][HTML] Quiescent endothelial cells upregulate fatty acid β-oxidation for vasculoprotection via redox homeostasis

J Kalucka, L Bierhansl, NV Conchinha, R Missiaen… - Cell metabolism, 2018 - cell.com
Little is known about the metabolism of quiescent endothelial cells (QECs). Nonetheless,
when dysfunctional, QECs contribute to multiple diseases. Previously, we demonstrated that …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

[HTML][HTML] N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia: A randomized controlled trial

Q Zhang, Y Ju, Y Ma, T Wang - Medicine, 2018 - journals.lww.com
Oxidative stress is considered to be part of the pathogenic mechanism for community-
acquired pneumonia (CAP) and is closely linked to inflammation. Attenuation of oxidative …

Tubulin acetylation: responsible enzymes, biological functions and human diseases

L Li, XJ Yang - Cellular and molecular life sciences, 2015 - Springer
Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …