Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …

Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA
regulation) is common in physiological and pathological conditions. Epigenetic alterations …

Epigenetic mechanisms involving the modulation of gene activity without modifying the DNA
bases are reported to have lifelong effects on mature neurons in addition to their impact on …

Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

DNA methylation is an epigenetic mechanism by which methyl groups are added to DNA,
playing a crucial role in gene expression regulation. The aim of the present study is to …

Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with
important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular …

Alzheimer's disease (AD) as the most prevalent dementia type has become one of the
greatest threats to the health and life of the elder people worldwide. Although there has …