Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
Antibody drugs should exhibit not only high-binding affinity for their target antigens but also
favorable physicochemical drug-like properties. Such drug-like biophysical properties are …
favorable physicochemical drug-like properties. Such drug-like biophysical properties are …
Targeting SARS-CoV-2 and host cell receptor interactions
SP Lim - Antiviral Research, 2023 - Elsevier
Despite the availability of vaccines and therapeutics, continual genetic alterations render the
severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat …
severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) a persistent threat …
CMC strategies and advanced technologies for vaccine development to boost acceleration and pandemic preparedness
MM Castellanos, H Gressard, X Li, C Magagnoli… - Vaccines, 2023 - mdpi.com
This review reports on an overview of key enablers of acceleration/pandemic and
preparedness, covering CMC strategies as well as technical innovations in vaccine …
preparedness, covering CMC strategies as well as technical innovations in vaccine …
COVID-19 therapeutics
Since the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options
has been studied and deployed. Healthcare providers have multiple treatment approaches …
has been studied and deployed. Healthcare providers have multiple treatment approaches …
SARS‐CoV‐2 neutralising antibody therapies: Recent advances and future challenges
The COVID‐19 pandemic represents an unparalleled global public health crisis. Despite
concerted research endeavours, the repertoire of effective treatment options remains limited …
concerted research endeavours, the repertoire of effective treatment options remains limited …
Intranasal delivery of thin-film freeze-dried monoclonal antibodies using a powder nasal spray system
Monoclonal antibodies (mAbs) administered intranasally as dry powders can be potentially
applied for the treatment or pre-exposure prevention of viral infections in the upper …
applied for the treatment or pre-exposure prevention of viral infections in the upper …
Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
GC Barnard, M Zhou, A Shen, IH Yuk… - Biotechnology …, 2024 - Wiley Online Library
Monoclonal antibodies (mAbs) are effective therapeutic agents against many acute
infectious diseases including COVID‐19, Ebola, RSV, Clostridium difficile, and Anthrax …
infectious diseases including COVID‐19, Ebola, RSV, Clostridium difficile, and Anthrax …
Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins
H Broly, J Souquet, A Beck - MAbs, 2023 - Taylor & Francis
The COVID-19 pandemic highlighted the urgent need for life-saving treatments, including
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
The gap between development and manufacturing in gene therapy: Strategic options for overcoming traps
Highlights•Gene therapy is becoming established in the treatment of rare diseases.•The
ease of starting clinical development has attracted startups, including those from academia.• …
ease of starting clinical development has attracted startups, including those from academia.• …
[HTML][HTML] Framework for valorizing waste-and by-products through insects and their microbiomes for food and feed
One third of the food produced for human consumption is currently lost or wasted. Insects
have a high potential for converting organic waste-and by-products into food and feed for a …
have a high potential for converting organic waste-and by-products into food and feed for a …