[HTML][HTML] Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer
Background Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is
associated with specific treatment exposures, unfavorable health behaviors, and presence …
associated with specific treatment exposures, unfavorable health behaviors, and presence …
[HTML][HTML] Parent-of-Origin inference for biobanks
Identical genetic variations can have different phenotypic effects depending on their parent
of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of …
of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of …
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations
YA Jakubek, AP Reiner, MC Honigberg - Translational Research, 2023 - Elsevier
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
Brain age estimation reveals older adults' accelerated senescence after traumatic brain injury
Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI).
Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain …
Nevertheless, the extent to which chronological age (CA) at injury affects TBI-related brain …
[HTML][HTML] DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses
Background Depression is a disabling and highly prevalent condition where genetic and
epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA …
epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA …
Characteristic hallmarks of aging and the impact on carcinogenesis
S Terracina, G Ferraguti, C Petrella… - Current Cancer Drug …, 2023 - ingentaconnect.com
Evidence shows that there is a synergistic, bidirectional association between cancer and
aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while …
aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while …
[HTML][HTML] Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
Background Previous studies have reported cross-sectional associations between
measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However …
measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However …
Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period
Background Measures of biological aging range from DNA methylation (DNAm)-based
estimates to measures of physical abilities. The purpose of this study was to compare DNAm …
estimates to measures of physical abilities. The purpose of this study was to compare DNAm …
The role of epigenetic clocks in explaining educational inequalities in mortality: A Multicohort study and meta-analysis
Educational inequalities in all-cause mortality have been observed for decades. However,
the underlying biological mechanisms are not well known. We aimed to assess the role of …
the underlying biological mechanisms are not well known. We aimed to assess the role of …
Associations between alcohol use and accelerated biological ageing
Harmful alcohol use is a leading cause of premature death and is associated with age‐
related disease. Biological ageing is highly variable between individuals and may deviate …
related disease. Biological ageing is highly variable between individuals and may deviate …