The causal relationship between gut microbiota and DNA methylation phenotypic age
acceleration remains unclear. This study aims to examine the causal effect of gut microbiota …

Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in
hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only …

Machine learning models based on DNA methylation can be used to predict the age of
biological 17 samples, but their interpretability is limited due to the lack of causal inferences …

DNA methylation (DNAm) clocks hold promise for measuring biological age, useful for
guiding clinical interventions and forensic identification. This study compared the commonly …

Background The causal relationship and the direction of the effect between depression and
aging remain controversial. Methods We used a bidirectional two-sample Mendelian …

Background Aging is a significant risk factor for many neurodegenerative diseases and
neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere …

Background An individual's biological age is a measurement of health status and provides a
mechanistic understanding of aging. Age clocks estimate a biological age of an individual …

Oxidative phosphorylation, essential for energy metabolism and linked to the regulation of
longevity, involves mitochondrial and nuclear genes. The functions of these genes and their …

Aging and cancer are clearly associated processes, at both the epidemiological and
molecular level. Epigenetic mechanisms are good candidates to explain the molecular links …

Elderly patients represent a growing proportion of individuals with glioblastoma, who
however, are often excluded from clinical trials owing to poor expected prognosis. We aimed …