The emergence of epigenetic predictors was a pivotal moment in geroscience, propelling
the measurement and concept of biological ageing into a quantitative era. However, while …

Background A new aging biomarker epigenetic clock has been developed. There exists a
close link between aging and gut microbiota, which may be mediated by inflammatory …

Hi-C is a widely applied chromosome conformation capture (3C)-based technique, which
has produced a large number of genomic contact maps with high sequencing depths for a …

Simple Summary Chronological aging has long been considered an immutable risk factor
for cerebral small vessel disease, but recent studies have revealed the potential for …

Longevity and disease-free survival are influenced by a combination of genetics and
lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may …

Human brain structure shows heterogeneous patterns of change across adults aging and is
associated with cognition. However, the relationship between cortical structural changes …

Aging and cancer are clearly associated processes, at both the epidemiological and
molecular level. Epigenetic mechanisms are good candidates to explain the molecular links …

Background Epigenetic clocks constructed from DNA methylation patterns have emerged as
excellent predictors of aging and aging-related health outcomes. Iron, a crucial element, is …

The causal relationship between gut microbiota and DNA methylation phenotypic age
acceleration remains unclear. This study aims to examine the causal effect of gut microbiota …

Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in
developed countries, and pathogenesis is closely related to aging. DNA methylation-based …