The incorporation of epigenetics (ie, change in gene activity without change in DNA
sequence) into studies of gene regulation and phenotypic expression has contributed to a …

Background Childhood maltreatment (CM) is linked to long-term adverse health outcomes,
including accelerated biological aging and cognitive decline. This study investigates the …

Solar lentigines (SLs) are a hallmark of human skin aging. They result from chronic
exposure to sunlight and other environmental stressors. Recent studies also imply genetic …

Human brain structure shows heterogeneous patterns of change across adults aging and is
associated with cognition. However, the relationship between cortical structural changes …

An increasing burden of neurological diseases (NDs) has been a public health challenge in
an aging society. Age, especially biological age, is the most important risk factor for NDs …

Background Exercise capacity (EC) and physical activity (PA) are independent, potentially
modifiable predictors of clinical outcomes in COPD. Molecular measures of biological age …

This work delves into the relationship between cardiovascular health (CVH) and aging.
Previous studies have shown an association of ideal CVH with a slower aging rate …

Background: Aging is a complex biological process that may be accelerated in certain
pathological conditions. DNA methylation age (DNAmAge) has emerged as a biomarker for …

Background and objectives In observational studies, women's fertility and sexual
development traits may have implications for DNA methylation patterns, and pregnancy …

Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in
developed countries, and pathogenesis is closely related to aging. DNA methylation-based …