Introduction Alzheimer's disease (AD) represents a global health crisis. Treatments are
needed to prevent, delay the onset, slow the progression, improve cognition, and reduce …

Introduction Drugs that prevent the onset, slow progression, or improve cognitive and
behavioral symptoms of Alzheimer's disease (AD) are needed. Methods We searched …

Systematic reviews should incorporate as much relevant evidence as possible to reduce
bias and research waste and increase reliability of results. Clinical trials registers are a key …

BACKGROUND: A growing body of evidence shows that sharing health research data with
other researchers for secondary analyses can contribute to better health. This is especially …

Background/Aims Informed clinical guidance and health policy relies on clinicians,
policymakers, and guideline developers finding comprehensive clinical evidence and …

Abstract Research and Development (R&D) in pharmaceuticals has often been judged as
suboptimal due to barriers to entry, including the required investment size and other factors …

Abstract Background Clinical outcome assessments (COAs) are key to patient‐centered
evaluation of novel interventions and supportive care. COAs are particularly informative in …

Registries were primarily set up to (i) increase the enrollment in trials and (ii) decrease the
bias in the published literature. Additionally, scholars have used registry data to answer a …

There is widespread agreement that clinical trials should be registered in a public registry,
preferably before the trial commences. It is also important that details of each trial in the …

We wished to determine whether rare diseases patients from India had been enrolled in
international trials to develop novel orphan drugs. There are two reasons to be interested in …