Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population,
and usually has an onset age at around 21–25 in males and 25–30 in females. Recent …

Depression is a serious and persistent psychiatric disorder that commonly first manifests
during childhood. Depression that starts in childhood is increasing in frequency, likely due …

Objective: Major depressive disorder (MDD) is highly heterogeneous. Standard typology
partly captures the disorder's symptomatic heterogeneity, although whether it adequately …

Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early
adulthood. Age at onset (AAO) of SCZ is associated with long-term outcomes of the disease …

Background Research findings on factors associated with onset‐age (OA) with bipolar (BD)
and major depressive disorders (MDD) have been inconsistent, but often indicate greater …

Background Benzodiazepine long-term use (BLTU) is a public health challenge. We lack
data on the consequences of LBTU on the trajectory of treatment-resistant depression …

The Mild Behavioral Impairment (MBI) concept was developed to determine whether late-
onset persistent neuropsychiatric symptoms (NPSs) may be early manifestations of cognitive …

Background The age of onset (AOO) is a key factor for heterogeneity in major depressive
disorder (MDD). Looking at the effect of AOO on symptomatology may improve clinical …

Human genetic studies indicate that suicidal ideation and behavior are both heritable. Most
studies have examined associations between aberrant gene expression and suicide …

Bipolar disorder is a heterogenous condition with a varied clinical presentation. While
progress has been made in identifying genetic variants associated with bipolar disorder …