L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …

Schizophrenia affects millions of people worldwide and is a major challenge for the scientific
community. Like most psychotic diseases, it is also considered a complicated mental …

Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …

The low replicability of scientific studies has become an important issue. One possible cause
is low representativeness of the experimental design employed. Already in the 1950's, Egon …

Xanthurenic acid (XA) raises a growing multidisciplinary interest based upon its oxidizing
properties, its ability to complex certain metal ions, and its detoxifier capacity of 3 …

Schizophrenia is a group of severe neurodevelopmental disorders. Identification of
peripheral diagnostic biomarkers is an effective approach to improving diagnosis of …

Neurodevelopmental disorders (NDDs) are complex disorders which can be associated with
many comorbidities and exhibit multifactorial-dependent phenotypes. An important …

Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …

Exposure to adversities in early life appears to affect the development of white matter,
especially oligodendrocytes. Furthermore, altered myelination is present in regions …

Antipsychotic drugs (APDs) are used to treat many psychiatric illnesses as schizophrenia.
Typical antipsychotic drugs (TAPDs) are being used; however, they have many side effects …