Scrutinizing Mycobacterium tuberculosis membrane and secretory proteins to formulate multiepitope subunit vaccine against pulmonary tuberculosis by utilizing …
Tuberculosis is a menacing disease caused eminently to the people inhabiting the tropical
and sub-tropical nations. A holistic approach is required to generate T and B memory cells to …
and sub-tropical nations. A holistic approach is required to generate T and B memory cells to …
Structural and energetic understanding of novel natural inhibitors of Mycobacterium tuberculosis malate synthase
Persistent infection by Mycobacterium tuberculosis requires the glyoxylate shunt. This is a
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
In-silico interaction studies suggest RND efflux pump mediates polymyxin resistance in Acinetobacter baumannii
P Verma, P Maurya, M Tiwari… - Journal of Biomolecular …, 2019 - Taylor & Francis
Bacterial efflux pumps have emerged as antibiotic resistance determinants and confers multi-
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …
Identification of novel natural inhibitors of Opisthorchis felineus cytochrome P450 using structure-based screening and molecular dynamic simulation
Opisthorchis felineus is the etiological agent of opisthorchiasis in humans. O. felineus
cytochrome P450 (OfCYP450) is an important enzyme in the parasite xenobiotic …
cytochrome P450 (OfCYP450) is an important enzyme in the parasite xenobiotic …
Developing a multi-epitope vaccine candidate to combat porcine epidemic diarrhea virus and porcine deltacoronavirus co-infection by employing an …
W Hou, H Wu, W Wang, R Wang, W Han… - Frontiers in …, 2023 - frontiersin.org
Coinfection of porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus
(PDCoV) is common in pig farms, but there is currently no effective vaccine to prevent this co …
(PDCoV) is common in pig farms, but there is currently no effective vaccine to prevent this co …
Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site
Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a crucial enzyme of the glyoxylate
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …
Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
Exploratory algorithm to devise multi-epitope subunit vaccine by investigating Leishmania donovani membrane proteins
Visceral leishmaniasis (VL) is a deadly parasitic infection which affects poorest to poor
population living in the endemic countries. Increasing resistant to existing drugs, disease …
population living in the endemic countries. Increasing resistant to existing drugs, disease …
Applications of Ensemble Docking in Potential Inhibitor Screening for Mycobacterium tuberculosis Isocitrate Lyase Using a Local Plant Database
Isocitrate lyase (ICL) is a persistent factor for the survival of dormant stage Mycobacterium
tuberculosis (MTB), thus a potential drug target for tuberculosis treatment. In this work …
tuberculosis (MTB), thus a potential drug target for tuberculosis treatment. In this work …
Structure-based discovery of phenyl-diketo acids derivatives as Mycobacterium tuberculosis malate synthase inhibitors
Mycobacterium tuberculosis remains one of the most successful bacterial pathogens
worldwide. The development of drug-resistant strains and the ability of the bacteria to persist …
worldwide. The development of drug-resistant strains and the ability of the bacteria to persist …