Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low
testosterone levels are associated with increased fat mass (particularly central adiposity) …

Background The cardiovascular safety of testosterone-replacement therapy in middle-aged
and older men with hypogonadism has not been determined. Methods In a multicenter …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Importance Recent studies have yielded conflicting results as to whether testosterone
treatment increases cardiovascular risk. Objective To test the hypothesis that testosterone …

Testosterone (T) is the principal male sex hormone. As men age, T levels typically fall.
Symptoms of low T include decreased libido, vasomotor instability, and decreased bone …

Abstract The Testosterone Trials (TTrials) were a coordinated set of seven placebo-
controlled, double-blind trials in 788 men with a mean age of 72 years to determine the …

Testosterone is the most important hormone in male health. Aging is characterized by
testosterone deficiency due to decreasing testosterone levels associated with low testicular …

Aims There is a significant uncertainty regarding the effect of testosterone replacement
therapy (TRT) on cardiovascular (CV) outcomes including myocardial infarction (MI) and …

Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …