Nature-Inspired Compounds: Synthesis and Antibacterial Susceptibility Testing of Eugenol Derivatives against H. pylori Strains

S Carradori, A Ammazzalorso, S Niccolai, D Tanini… - Pharmaceuticals, 2023 - mdpi.com
The antimicrobial properties of one of the most important secondary metabolites, Eugenol
(EU), inspired us to design and synthesize three different series of derivatives enhancing its …

In silico screening and in vivo experimental validation of 15-PGDH inhibitors from traditional Chinese medicine promoting liver regeneration

C Feng, C Qiao, W Ji, H Pang, L Wang, Q Feng… - International Journal of …, 2024 - Elsevier
Abstract The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which acts as a
negative regulator of prostaglandin E2 (PGE2) levels and activity, represents a promising …

Identification of natural Rutaecarpine as a potent tobacco mosaic virus (TMV) helicase candidate for managing intractable plant viral diseases

ZX Li, JH Hu, RS Luo, TH Zhang, Y Ding… - Pest Management …, 2024 - Wiley Online Library
BACKGROUND Naturally occurring alkaloids are particularly suitable for use as pesticide
precursors and further modifications due to their cost‐effectiveness, unique mechanism of …

[HTML][HTML] Design, synthesis, and evaluation of novel 3-(piperazin-1-yl) propan-2-ol-modified carbazole derivatives targeting the bacterial membrane

SY Ma, YG Ding, XX Tuo, GQ Wang, HW Liu… - Arabian Journal of …, 2024 - Elsevier
Grain of high yield and quality is needed worldwide due to the needs of a rapidly increasing
human population. However, diseases caused by some stubborn types of phytopathogenic …

Identification of novel 4-substituted 7H-pyrrolo [2, 3-d] pyrimidine derivatives as new FtsZ inhibitors: Bioactivity evaluation and computational simulation

T Li, Y Zhou, X Fu, L Yang, H Liu, X Zhou, L Liu… - Bioorganic …, 2024 - Elsevier
Bacterial infections and the consequent outburst of bactericide-resistance issues are fatal
menace to both global health and agricultural produce. Hence, it is crucial to explore …

[HTML][HTML] Plant antiviral compounds containing pyrazolo [3, 4-d] pyrimidine based on the systemin receptor model

Y Wang, Z Zhao, R Guo, Y Tang, S Guo, Y Xu… - Arabian Journal of …, 2024 - Elsevier
Introduction The development of small molecule modulators rooted the plant resistance
mechanism represents a compelling strategy for improving plant resistance and fortifying …

Synthesis and antifungal activity of coumarin derivatives containing hydrazone moiety

Z Zhang, D Geng, Z Yang, L Pan… - Chemistry & …, 2024 - Wiley Online Library
Plant disease control mainly relies on pesticides. In this study, a series of coumarin
derivatives containing hydrazone moiety were designed and synthesized. The synthesized …

Structurally Diverse Coumarins from Peucedanum praeruptorum and their Anti‐Inflammatory Activities via NF‐κB Signaling Pathway

KQ Lin, HF Liu, C Chen, JY Li, WD Pan… - Chemistry & …, 2024 - Wiley Online Library
The phytochemical study of Peucedanum praeruptorum led to the isolation of twenty‐five
coumarins (1‐25). Of which,(±) praeruptol A (±1), one pair of previous undescribed seco …

The Antiviral Potential of Perilla frutescens: Advances and Perspectives

J Chen, Y Zhao, J Cheng, H Wang, S Pan, Y Liu - Molecules, 2024 - mdpi.com
Viruses pose a significant threat to human health, causing widespread diseases and
impacting the global economy. Perilla frutescens, a traditional medicine and food …