High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …

Background Nature has gifted a variety of vital phytochemicals having potential therapeutic
application against various ailments. Emblica officinalis (E. officinalis), an ancient plant, has …

Although white AT can contribute to anti-infectious immune responses, it can also be
targeted and perturbed by pathogens. The AT's immune involvement is primarily due to …

For long time bilirubin was only considered as a potentially dangerous sign of liver diseases,
but it now appears clear that it is also a powerful signaling molecule. Together with potent …

Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism …

Liver cirrhosis is a form of liver fibrosis resulting from chronic hepatitis caused by various
liver diseases, such as viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis …