[HTML][HTML] Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Y Jia, L Yu, T Ma, W Xu, H Qian, Y Sun, H Shi - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles, especially small extracellular vesicles (sEVs) are now accepted as
important messengers in cell-to-cell communication and as a promising drug delivery …

[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA

X Chen, Z Wan, L Yang, S Song, Z Fu, K Tang… - Journal of …, 2022 - Springer
Background Periodontitis is characterized by progressive inflammation and alveolar bone
loss resulting in tooth loss finally. Macrophages including pro-inflammatory M1-like …

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

DD Shen, JR Pang, YP Bi, LF Zhao, YR Li, LJ Zhao… - Molecular cancer, 2022 - Springer
Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to
be significantly elevated in gastric cancer (GC) and may be associated with the proliferation …

Engineering extracellular vesicles as delivery systems in therapeutic applications

L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

Nano-drug delivery system targeting tumor microenvironment: a prospective strategy for melanoma treatment

M Xu, S Li - Cancer Letters, 2023 - Elsevier
Melanoma, the most aggressive form of cutaneous malignancy arising from melanocytes, is
frequently characterized by metastasis. Despite considerable progress in melanoma …

[HTML][HTML] Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research

B Ma, S Wang, W Wu, P Shan, Y Chen, J Meng… - Biomedicine & …, 2023 - Elsevier
In recent years, breakthroughs in bioinformatics have been made with the discovery of many
functionally significant non-coding RNAs (ncRNAs). The discovery of these ncRNAs has …

Exosomes: another intercellular lipometabolic communication mediators in digestive system neoplasms?

S Li, R Dong, Z Kang, H Li, X Wu, T Li - Cytokine & growth factor reviews, 2023 - Elsevier
Neoplasms are one of the most concerned public health problems worldwide. Digestive
system neoplasms, with a high morbidity and mortality, is one of the most common malignant …

Emerging role of exosomes as biomarkers in cancer treatment and diagnosis

NA Hanjani, N Esmaelizad, S Zanganeh… - Critical reviews in …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and cancer incidence and mortality are
rapidly growing. These massive amounts of cancer patients require rapid diagnosis and …

Exosomal-long non-coding RNAs journey in colorectal cancer: Evil and goodness faces of key players

NI Rizk, AI Abulsoud, MM Kamal, DH Kassem… - Life sciences, 2022 - Elsevier
Exosomes are nano-vesicles (NVs) secreted by cells and take part in cell-cell
communications. Lately, these exosomes were proved to have dual faces in cancer …