Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases
JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme
INTRODUCTION Discrimination of self from nonself is pivotal for cellular organisms, as it
allows the perception of pathogenic invaders that might otherwise multiply unchecked and …
allows the perception of pathogenic invaders that might otherwise multiply unchecked and …
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation …
M Moustaqil, E Ollivier, HP Chiu, S Van Tol… - Emerging microbes & …, 2021 - Taylor & Francis
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of
nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian …
nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian …
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ
INTRODUCTION Plants and animals respond to pathogen invasion through intracellular
nucleotide-binding leucine-rich repeat receptors (NLRs) that directly interact with pathogen …
nucleotide-binding leucine-rich repeat receptors (NLRs) that directly interact with pathogen …
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
Cyclic nucleotide-induced helical structure activates a TIR immune effector
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life.
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …
Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in …
[HTML][HTML] Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia/reperfusion injury via inhibiting TXNIP and the TLR4/NF-κB/NLRP3 …
Y Dai, S Wang, S Chang, D Ren, S Shali, C Li… - Journal of molecular and …, 2020 - Elsevier
Background Reperfusion may cause injuries to the myocardium in ischemia situation.
Emerging studies suggest that exosomes may serve as key mediators in myocardial …
Emerging studies suggest that exosomes may serve as key mediators in myocardial …