Background Data are scarce regarding the development of hepatic decompensation in
patients with non-alcoholic fatty liver disease (NAFLD) with and without type 2 diabetes. We …

Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …

The process of tissue regeneration requires the utilization of a scaffold, which serves as a
structural framework facilitating cellular adhesion, proliferation, and migration within a …

We report a multi-ancestry genome-wide association study on liver cirrhosis and its
associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase …

Conclusions: This consensus-driven multidisciplinary fatty liver disease action agenda
developed by care providers, clinical researchers, and public health and policy experts …

Background High body mass index (BMI) is a major risk factor for cancer development, but
its impact on the global burden of cancer remains unclear. Methods We estimated global …

Background & Aims Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but
it is unclear how family history may be used to identify first-degree relatives with advanced …

Hepatocellular carcinoma (HCC) is the third lead-ing cause of cancer-related death globally.
The burden of nonalcoholic steatohepatitis (NASH) and alcohol-related HCC has increased …

The accumulation of extracellular matrix (ECM) proteins in the liver leads to liver fibrosis and
end-stage liver cirrhosis. CC motif chemokine receptor 2 (CCR2) is an attractive target for …

Many countries have incorporated population screening programmes for cancer, such as
colorectal and lung cancer, into their health-care systems. Cirrhosis is more prevalent than …