Common etiologies of acute traumatic peripheral nerve injury (TPNI) include penetrating
injury, crush, stretch, and ischemia. Management of TPNI requires familiarity with the …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

Experimental models such as the facial nerve axotomy paradigm in rodents allow the
systematic and detailed study of the response of neurones and their microenvironment to …

Distinguishing the primary from secondary effects and compensatory mechanisms is of
crucial importance in understanding adult-onset neurodegenerative diseases such as …

An analysis of programmed cell death of several populations of developing postmitotic
neurons after genetic deletion of two key members of the caspase family of pro-apoptotic …

Much confusion has arisen recently over the question of whether excitotoxic neuronal
degeneration can be considered an apoptotic phenomenon. Here, we addressed this …

Spinal muscular atrophy (SMA) is caused by mutations/deletions within the SMN1 gene and
characterized by loss of lower motor neurons and skeletal muscle atrophy. SMA is clinically …

The mechanisms for motor neuron degeneration and regeneration in adult spinal cord
following axotomy and target deprivation are not fully understood. We used a unilateral …

During the development of the nervous system, a large number of neurons are eliminated
through naturally occurring neuronal death. Many morphological and biochemical properties …

The mechanisms of injury‐induced apoptosis of neurons within the spinal cord are not
understood. We used a model of peripheral nerve‐spinal cord injury in the rat and mouse to …