Systemic sclerosis

ER Volkmann, K Andréasson, V Smith - The Lancet, 2023 - thelancet.com
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune
connective-tissue disease. Once considered an untreatable and unpredictable condition …

The flare of rheumatic disease after SARS-CoV-2 vaccination: a review

Y Xie, Y Liu, Y Liu - Frontiers in Immunology, 2022 - frontiersin.org
As the coronavirus disease 2019 (COVID-19) pandemic continues worldwide, vaccination
has been considered an effective measure to protect people from the COVID-19 and end the …

Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression

M Prendecki, C Clarke, H Edwards… - Annals of the …, 2021 - ard.bmj.com
Objective There is an urgent need to assess the impact of immunosuppressive therapies on
the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T …

Rituximab, but not other antirheumatic therapies, is associated with impaired serological response to SARS-CoV-2 vaccination in patients with rheumatic diseases

R Spiera, S Jinich, D Jannat-Khah - Annals of the rheumatic diseases, 2021 - ard.bmj.com
There is a paucity of data on the effect of antirheumatic drugs on serological responses to
COVID-19 vaccines. Anti-CD20 therapies deplete B-cells, with reconstitution often not …

Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective cohort

S Ahmed, P Mehta, A Paul, S Anu, S Cherian… - Annals of the …, 2022 - ard.bmj.com
Introduction To assess the incidence and risk factors for breakthrough COVID-19 infection in
a vaccinated cohort of patients with autoimmune rheumatic diseases (AIRDs) and determine …

Clinical characteristics and outcomes of COVID-19 breakthrough infections among vaccinated patients with systemic autoimmune rheumatic diseases

C Cook, NJ Patel, KM D'Silva, TYT Hsu… - Annals of the …, 2022 - ard.bmj.com
SARS-CoV-2 vaccines reduce the risk of COVID-19. 1–3 However, some disease-modifying
anti-rheumatic drugs (DMARDs), particularly glucocorticoids, methotrexate, mycophenolate …

Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

CSR Araujo, AC Medeiros-Ribeiro… - Annals of the …, 2022 - ard.bmj.com
Objective To evaluate the effect on immunogenicity and safety of 2-week methotrexate
(MTX) discontinuation after each dose of the Sinovac-CoronaVac vaccine versus MTX …

Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study

M Shrotri, E Fragaszy, V Nguyen… - Nature …, 2022 - nature.com
Vaccination constitutes the best long-term solution against Coronavirus Disease-2019;
however, vaccine-derived immunity may not protect all groups equally, and the durability of …

Myasthenic crisis

B Claytor, SM Cho, Y Li - Muscle & Nerve, 2023 - Wiley Online Library
Myasthenic crisis (MC) is a life‐threatening manifestation of myasthenia gravis (MG) defined
by respiratory insufficiency that requires the use of invasive or non‐invasive ventilation. This …

Impaired antibody response to the BNT162b2 messenger RNA coronavirus disease 2019 vaccine in patients with systemic lupus erythematosus and rheumatoid …

C Ammitzbøll, LE Bartels… - ACR open …, 2021 - Wiley Online Library
Objective With a vaccine effectiveness of 95% for preventing coronavirus disease 2019
(COVID‐19), Pfizer‐BioNTech BNT162b2 (BNT162b2) was the first vaccine against severe …