Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has
caused the death of nearly six million people worldwide. Emerging data have identified a …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Aging is a normal, progressive and multi-step degeneration in the physiological functions
and metabolic processes of living organisms until death. It represents the main risk factor for …

Diabetes-induced vascular endothelial dysfunction has been reported to involve
hyperglycemia-induced increases in arginase activity. However, upstream mediators of this …

Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction
(VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …

This special issue, entitled “the role of arginase in endothelial dysfunction,” assembles
original contributions (1–4), as well as timely reviews (5–12) broadly related to the …

Background & aims Excess nutrient supply, such as high fat and high glucose intake,
promotes oxidative stress and advanced glycation end products accumulation. Oxidative …