Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities

A Corona, K Wycisk, C Talarico, C Manelfi… - ACS pharmacology & …, 2022 - ACS Publications
SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

B Canal, AW McClure, JF Curran, M Wu… - Biochemical …, 2021 - portlandpress.com
SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world
causing a deadly pandemic with tremendous social and economic costs. Healthcare …

SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

SY Fung, KL Siu, H Lin, CP Chan, ML Yeung, DY Jin - Cell & bioscience, 2022 - Springer
Background SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release
of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of …

Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

AL Pinto, RK Rai, JC Brown, P Griffin, JR Edgar… - Nature …, 2022 - nature.com
Ultrastructural studies of SARS-CoV-2 infected cells are crucial to better understand the
mechanisms of viral entry and budding within host cells. Here, we examined human airway …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

CT Lim, KW Tan, M Wu, R Ulferts… - Biochemical …, 2021 - portlandpress.com
The COVID-19 pandemic has emerged as the biggest life-threatening disease of this
century. Whilst vaccination should provide a long-term solution, this is pitted against the …

COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

JC Milligan, TU Zeisner, G Papageorgiou… - Biochemical …, 2021 - portlandpress.com
The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented …

Comprehensive fragment screening of the SARS‐CoV‐2 proteome explores novel chemical space for drug development

H Berg, MA Wirtz Martin, N Altincekic… - Angewandte Chemie …, 2022 - Wiley Online Library
Abstract SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the
public health. The variants increased challenges to vaccines, thus necessitating for …