Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and
their multi-cellular interactions. To understand these dependencies within the wider …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones
caused by the acquisition of somatic point mutations or mosaic chromosomal alterations …

Genetic predisposition (familial risk) in the myeloproliferative neoplasms (MPNs) is more
common than the risk observed in most other cancers, including breast, prostate, and colon …

Quantifying an individual's risk for common diseases is an important goal of precision health.
The polygenic risk score (PRS), which aggregates multiple risk alleles of candidate …

Background: Ageing is a heterogenous process characterised by cellular and molecular
hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for …

Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …