Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death

DS Simpson, H Anderton, J Yousef, V Vaibhav… - PNAS …, 2024 - academic.oup.com
Skin inflammation is a complex process implicated in various dermatological disorders. The
chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the …

The anti-inflammatory effect of Aptamin C on House dust mite extract-induced inflammation in keratinocytes via regulation of IL-22 and GDNF production

D Lee, Y Kim, H Jo, C Go, Y Jeong, Y Jang, D Kang… - Antioxidants, 2021 - mdpi.com
Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by eczemous
lesions on the skin that manifest as severe itching and last a long time. AD is thought to be a …

Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3

J Lei, M Tominaga - BioEssays, 2024 - Wiley Online Library
Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding
elucidated how thermosensation is affected by TRPV3 membrane abundance that is …

Calcium-Based Antimicrobial Peptide Compounds Attenuate DNFB-Induced Atopic Dermatitis-Like Skin Lesions via Th-Cells in BALB/c Mice

Q Liu, M Li, N Wang, C He, X Jiang, J Li - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease, characterized by
severe itching and recurrent skin lesions. We hypothesized that a novel treatment involving …

Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene …

J Ahn, S Shin, GC Lee, BE Han, E Lee, EK Ha… - Allergology …, 2024 - jstage.jst.go.jp
Background: Atopic dermatitis and autoimmune diseases are highly heritable conditions that
may co-occur from an early age. Methods: The primary study is a national administrative …

[HTML][HTML] The interaction between NK cells and ILC cells and their subsets in atopic dermatitis patients with and without dupilumab therapy

P Boudkova, E Čermáková, J Krejsek… - International …, 2024 - Elsevier
Background Natural killer cells (NK) and innate lymphoid cells with their subsets (ILC) are
part of the innate immune system. Objective The aim is to evaluate how NK cells and ILC …

Possible roles of CXCL13/CXCR5 axis in the development of bullous pemphigoid

K Ohuchi, T Fujimura, C Lyu, R Amagai… - The Journal of …, 2021 - Wiley Online Library
CXCL13 recruits CXCR5+ follicular helper T (Tfh) cells in inflammatory lesions to develop
secondary lymphoid organs. Tfh cells activate B cells to produce antibodies during humoral …

Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis

M Acharya, R Gautam, SJ Yang, JH Jo… - Laboratory Animal …, 2024 - Springer
Background Atopic dermatitis (AD) is a biphasic type of skin inflammation characterized by a
predominance of type-2 (TH2) and type-1 (TH1) helper T cell-biased immune responses at …

Therapeutic effect of chinese herbal medicine gu-ben-hua-shi (AESS) formula on atopic dermatitis through regulation of yes-associated protein

J Jia, L Feng, S Ye, R Ping, X Mo, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Atopic dermatitis (AD) is a chronic and recurrent skin disease. At present, there
is a lack of sufficiently effective and safe medicines that can be used for a prolonged time …

[HTML][HTML] Onset of multiple sclerosis in a patient on dupilumab therapy for atopic dermatitis: A case report

F Gelato, L Mastorino, P Cavalla, P Quaglino… - Dermatologic …, 2022 - ncbi.nlm.nih.gov
Dear Editor, A 21-year-old male patient affected by severe atopic dermatitis (AD) since
childhood started dupilumab in January 2019 after treatment failure with cyclosporin. Serum …