[HTML][HTML] Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

LFC Pedrosa, ANAB Barros, L Leite-Lais - Clinical nutrition ESPEN, 2022 - Elsevier
The pathogenicity of the current coronavirus disease (COVID-19) shows postulates that
optimal status of essential nutrients is crucial in supporting both the early viraemic and later …

[HTML][HTML] Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis

A Beran, M Mhanna, O Srour, H Ayesh, JM Stewart… - Clinical nutrition …, 2022 - Elsevier
Background and aims Micronutrient supplements such as vitamin D, vitamin C, and zinc
have been used in managing viral illnesses. However, the clinical significance of these …

Vitamin C supplementation for the treatment of COVID-19: A systematic review and meta-analysis

M Olczak-Pruc, D Swieczkowski, JR Ladny, M Pruc… - Nutrients, 2022 - mdpi.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by the
severe respiratory syndrome coronavirus 2 (SARS-CoV-2), millions of people have died …

Intravenous vitamin C use and risk of severity and mortality in COVID‐19: a systematic review and meta‐analysis

G Ao, J Li, Y Yuan, Y Wang, B Nasr… - Nutrition in Clinical …, 2022 - Wiley Online Library
The administration of intravenous vitamin C (IV‐VC) in treating patients with coronavirus
disease 2019 (COVID‐19) is still highly controversial. There have been no previous studies …

Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: A propensity score matched study

K Al Sulaiman, O Aljuhani, KB Saleh, HA Badreldin… - Scientific reports, 2021 - nature.com
Ascorbic acid represents an appealing option for clinicians to utilize in the context of the
global COVID-19 pandemic due to its proposed clinical efficacy, relative safety, and low cost …

[HTML][HTML] The effectiveness of high-dose intravenous vitamin C for patients with coronavirus disease 2019: a systematic review and meta-analysis

SG Kwak, YJ Choo, MC Chang - Complementary therapies in medicine, 2022 - Elsevier
Objectives Vitamin C has anti-inflammatory effects. This review aimed to investigate the
therapeutic effect of high-dose intravenous vitamin C (HDIVC) in patients with coronavirus …

[PDF][PDF] The role of vitamin C in human immunity and its treatment potential against COVID-19: a review article

A Moore, D Khanna - Cureus, 2023 - cureus.com
The outbreak of the COVID-19 pandemic has left clinicians around the world searching for
viable prevention and treatment options to use against the virus. The important physiologic …

Vitamin C intervention for critical COVID-19: A pragmatic review of the current level of evidence

P Holford, AC Carr, M Zawari, MP Vizcaychipi - Life, 2021 - mdpi.com
Severe respiratory infections are characterized by elevated inflammation and generation of
reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as …

Vitamins C and D and COVID-19 susceptibility, severity and progression: an evidence based systematic review

F Migliorini, R Vaishya, J Eschweiler, F Oliva… - Medicina, 2022 - mdpi.com
Background and Objectives: Starting in early December 2019, the novel Coronavirus
Disease (COVID-19) from infection with COVID-19 has caused a global pandemic. Many …