Activated signaling cascades in the proximal tubular cells of the kidneys play a crucial role in
the development of tubulointerstitial fibrosis. Inhibition of these signaling cascades with …

Do kinases cascade? How well is cell regulation understood? What are the best ways to
model regulatory systems? Attempts to answer such questions can have bearings on the …

Primary cilia (PC) are solitary, sensory organelles that are critical for several signaling
pathways. PC were detected by immunofluorescence of cultured cells and breast tissues …

Understanding why certain patients with IgA nephropathy progress to kidney failure while
others maintain normal kidney function remains a major unanswered question. To help …

Background Epigenetic mechanisms may be important in the progression of chronic kidney
disease (CKD). Methods We studied the genome-wide DNA methylation pattern associated …

Kidney diseases have become a global public health problem. The application of kidney‐
targeted drug‐delivery systems in the management of kidney diseases has profound …

Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining
pathological features are fluid-filled cysts developing from nephric tubules due to defective …

Epigenetic modifications are important in the normal functioning of the cell, from regulating
dynamic expression of essential genes and associated proteins to repressing those that are …

In this study, we describe the generation and partial characterization of Krüppel-like zinc
finger protein Glis3 mutant (Glis3zf/zf) mice. These mice display abnormalities very similar to …

Background miR-214 was demonstrated to be upregulated in models of renal disease and
promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the …