Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages …

Ischemic stroke is a leading cause of disability and there is a paucity of therapeutic
strategies that promote functional recovery after stroke. Transcutaneous vagus nerve …

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction
leading to neurological deficits. Beyond the hyper-acute phase of ischaemic stroke, there is …

Impairments in dexterous upper limb function are a significant cause of disability following
stroke. While the physiological basis of movement deficits consequent to a lesion in the …

Background and Objectives Precise measurement of outcomes is essential for stroke trials
and clinical care. Prior research has highlighted conceptual differences between global …

Functional alterations after ischemic stroke have been described with Magnetic Resonance
Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on in vivo …

Real-time functional MRI neurofeedback allows individuals to self-modulate their ongoing
brain activity. This may be a useful tool in clinical disorders that are associated with altered …

The restoration of gait and mobility after stroke is an important and challenging therapy goal
due to the complexity of the potentially impaired functions. As a result, precise and clinically …

Astrocytes experience significant metabolic shifts in the “sensitive period” of neurological
function recovery following cerebral ischemia. However, the changes in astrocyte lipid …

Background Caloric restriction promotes neuroplasticity and recovery after neurological
injury. In mice, we tested the hypothesis that caloric restriction can act post-stroke to …