Analysis of SARS-CoV-2 mutations associated with resistance to therapeutic monoclonal antibodies that emerge after treatment.

D Focosi, S McConnell, DJ Sullivan… - Drug Resistance Updates, 2023 - Elsevier
The mutation rate of the Omicron sublineage has led to baseline resistance against all
previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …

New clinical trial design in precision medicine: discovery, development and direction

XP Duan, BD Qin, XD Jiao, K Liu, Z Wang… - Signal Transduction and …, 2024 - nature.com
In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

COVID-19 therapeutics

D Focosi, M Franchini, F Maggi… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Since the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options
has been studied and deployed. Healthcare providers have multiple treatment approaches …

Impact of structural modifications of IgG antibodies on effector functions

T Damelang, M Brinkhaus, TLJ van Osch… - Frontiers in …, 2024 - frontiersin.org
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …

COVID-19 and long-COVID thrombosis: from clinical and basic science to therapeutics

F Violi, J Harenberg, P Pignatelli… - Thrombosis and …, 2023 - thieme-connect.com
Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung
disease and thrombotic events in the venous and circulation trees, which represent a …

SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs

S Iketani, DD Ho - Cell Chemical Biology, 2024 - cell.com
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific
response has been rapid and effective, with many therapeutic monoclonal antibodies and …

Evolution of the SARS-CoV-2 Omicron Variants: Genetic Impact on Viral Fitness

W Liu, Z Huang, J Xiao, Y Wu, N Xia, Q Yuan - Viruses, 2024 - mdpi.com
Over the last three years, the pandemic of COVID-19 has had a significant impact on
people's lives and the global economy. The incessant emergence of variant strains has …

Pooling Different Placebos as a Control Group in a Randomized Platform Trial: Benefits and Challenges From Experience in the ACTIV-2 COVID-19 Trial

CB Moser, KW Chew, J Ritz, M Newell… - The Journal of …, 2023 - academic.oup.com
Adaptive platform trials were implemented during the coronavirus disease 2019 (COVID-19)
pandemic to rapidly evaluate therapeutics, including the placebo-controlled phase 2/3 …

The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis

S Singh, S Boyd, WHK Schilling… - Journal of …, 2024 - academic.oup.com
Background Effective antiviral drugs accelerate viral clearance in acute COVID-19
infections; the relationship between accelerating viral clearance and reducing severe …

Association between anterior nasal and plasma SARS-CoV-2 RNA levels and hospitalization or death in nonhospitalized adults with mild-to-moderate COVID-19

MJ Giganti, KW Chew, JJ Eron, JZ Li… - The Journal of …, 2023 - academic.oup.com
Background There is little information regarding severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA as a predictor for clinical outcomes in outpatients with …