Adult stem cells are fundamental to maintain tissue homeostasis, growth, and regeneration.
They reside in specialized environments called niches. Following activating signals, they …

Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease.
Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin …

Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate
different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the …

Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …

Specialized niches support the lifelong maintenance and function of tissue-specific stem
cells. Adult neural stem cells in the ventricular-subventricular zone (V-SVZ) contact the …

The “amyloid hypothesis” has dominated Alzheimer research for more than 20 years, and
proposes that amyloid is the toxic cause of neural/synaptic damage and dementia. If correct …

It is generally considered that Parkinson's disease is induced by specific agents that
degenerate a clearly defined population of dopaminergic neurons. Data commented in this …

Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain. The
ventricular–subventricular zone (V‐SVZ), adjacent to the lateral ventricles, gives rise to …

Primary astrocytomas of grade 3 or 4 according to the classification system of the World
Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults …

Highlights•Stem cells span different compartments of the niche and integrate both local and
long-range signals.•Anchorage to the niche, biophysical properties of the niche, such as …