Sex differences in depression: Insights from clinical and preclinical studies

RS Eid, AR Gobinath, LAM Galea - Progress in neurobiology, 2019 - Elsevier
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Gender differences in depression: biological, affective, cognitive, and sociocultural factors

JS Hyde, AH Mezulis - Harvard review of psychiatry, 2020 - journals.lww.com
The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …

Adverse childhood experiences, the serotonergic system, and depressive and anxiety disorders in adulthood: a systematic literature review

RK Lipsky, CC McDonald, MC Souders… - Neuroscience & …, 2022 - Elsevier
Background Recent studies have examined the role that the serotonergic system plays in
moderating the association between adverse childhood experiences (ACEs) and depressive …

Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

EL Gibson - Proceedings of the Nutrition Society, 2018 - cambridge.org
The neurotransmitter serotonin has a role in affective disorders such as depression and
anxiety, as well as sleep, cognitive function and appetite. This review examines the …

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

AD Volgin, OA Yakovlev, KA Demin… - Journal of …, 2019 - Wiley Online Library
Currently becoming widely recognized, personalized psychiatry focuses on unique
physiological and genetic profiles of patients to best tailor their therapy. However, the role of …

[HTML][HTML] Ahi1 regulates serotonin production by the GR/ERβ/TPH2 pathway involving sexual differences in depressive behaviors

B Wang, H Shi, L Ren, Z Miao, B Wan, H Yang… - Cell Communication and …, 2022 - Springer
Background Depression is one of the most common psychiatric diseases. The monoamine
transmitter theory suggests that neurotransmitters are involved in the mechanism of …

Structural brain alterations in older adults exposed to early-life adversity

ML Ancelin, I Carrière, S Artero, JJ Maller… - …, 2021 - Elsevier
Background Adverse childhood events may have differential effects on the brain that persist
into adulthood. Findings on structural brain alterations in older adults exposed to early-life …

Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism

L Wagels, M Votinov, S Radke, B Clemens… - Human brain …, 2017 - Wiley Online Library
Testosterone, a male sex hormone, has been suggested to partly explain mixed findings in
males and females when investigating behavioral tendencies associated with the MAOA …

[HTML][HTML] Age-related cognitive decline and the olfactory identification deficit are associated to increased level of depression

F Sanna, F Loy, R Piras, A Moat… - Frontiers in neuroscience, 2021 - frontiersin.org
Purpose Previous studies reported a correlation between olfactory function and depression.
However, in literature, no data are available for the correlation between depression and all …

Exogenous testosterone and the monoamine-oxidase A polymorphism influence anger, aggression and neural responses to provocation in males

L Wagels, M Votinov, T Kellermann, J Konzok… - …, 2019 - Elsevier
Testosterone and the monoamine oxidase-A (MAOA) polymorphism are potential
neuromodulators for aggression. By acting on similar brain circuits, they might interactively …