Pathophysiology and treatment of stroke: present status and future perspectives

D Kuriakose, Z Xiao - International journal of molecular sciences, 2020 - mdpi.com
Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain

MP Jurkowski, L Bettio, E K. Woo, A Patten… - Frontiers in cellular …, 2020 - frontiersin.org
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

[HTML][HTML] MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat

Y Chen, J Li, B Ma, N Li, S Wang, Z Sun, C Xue… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals
worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem …

Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

Concise review: mesenchymal stem cells in neurodegenerative diseases

R Volkman, D Offen - Stem cells, 2017 - academic.oup.com
Stem cell-based therapies for neurodegenerative diseases aim at halting clinical
deterioration by regeneration and by providing local support for damaged tissue …

Diverse roles for VEGF-A in the nervous system

F Mackenzie, C Ruhrberg - Development, 2012 - journals.biologists.com
Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood
vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of …

Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus

L Ding, H Sun, J Su, N Lin, B Péault, T Song, J Yang… - Biomaterials, 2014 - Elsevier
Serious injuries of endometrium in women of reproductive age are often followed by uterine
scar formation and a lack of functional endometrium predisposing to infertility or miscarriage …

Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

[HTML][HTML] Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics

Y Zhu, J Ge, C Huang, H Liu, H Jiang - Theranostics, 2021 - ncbi.nlm.nih.gov
Aging frailty is a complex geriatric syndrome that becomes more prevalent with advancing
age. It constitutes a major health problem due to frequent adverse outcomes. Frailty is …