Integrating biology into clinical trial design

RBE van Amstel, LA van Vught… - Current Opinion in Critical …, 2023 - journals.lww.com
Integrating our knowledge on biological heterogeneity into clinical trial design, which has
revolutionized other medical fields, could serve as a solution to implement personalized …

[PDF][PDF] Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial

C Sylvie, B Lila, D Claire… - Annals of …, 2023 - annalsofintensivecare.springeropen …
Background The respective benefits of high and low doses of dexamethasone (DXM) in
patients with severe acute respiratory syndrome coronavirus 2 (SARS‑Cov2) and acute …

Precision medicine for corticotherapy in COVID-19

D Annane, GU Meduri - Intensive Care Medicine, 2022 - Springer
Of the many lessons to draw from the coronavirus disease 2019 (COVID-19) pandemic is the
need to implement precision medicine for critical illnesses without delay. COVID-19 was …

[PDF][PDF] Machine learning-based COVID-19 acute respiratory distress syndrome phenotyping and clinical outcomes: A systematic review

ED Tenda, J Henrina, J Samosir, R Amalia, M Yulianti… - Heliyon, 2023 - cell.com
COVID-19-related acute respiratory distress syndrome (CARDS) has been suggested to
differ from the typical ARDS. While distinct phenotypes of ARDS have been identified …

Association between sub-phenotypes identified using latent class analysis and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan

H Tamura, H Yasuda, T Oishi, Y Shinzato… - BMC Cardiovascular …, 2024 - Springer
Background In patients who experience out-of-hospital cardiac arrest (OHCA), it is important
to assess the association of sub-phenotypes identified by latent class analysis (LCA) using …

Phenotypes and Lung Microbiota Signatures of Immunocompromised Patients with Pneumonia-Related Acute Respiratory Distress Syndrome

Y Hu, J Shen, Y An, Y Jiang, H Zhao - Journal of Inflammation …, 2024 - Taylor & Francis
Objective We aim to identify the clinical phenotypes of immunocompromised patients with
pneumonia-related ARDS, to investigate the lung microbiota signatures and the outcomes of …

Post–Intensive Care Syndrome in COVID-19 versus Non–COVID-19 Critical Illness Survivors: More Similar than Not?

MR Baldwin, GL Anesi - … Journal of Respiratory and Critical Care …, 2022 - atsjournals.org
At the outset of the coronavirus disease (COVID-19) pandemic, some observers reported
differences between COVID-19 acute respiratory distress syndrome (ARDS) and non …

Heterogeneity, Bayesian thinking, and phenotyping in critical care: A primer

TW Jones, T Hendrick, AM Chase - American Journal of Health …, 2024 - academic.oup.com
Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts
online as soon as possible after acceptance. Accepted manuscripts have been peer …

A Nomogram for Predicting Mortality in Patients with Pneumonia-Associated Acute Respiratory Distress Syndrome (ARDS)

D Huang, D He, L Gong, W Jiang, R Yao… - Journal of Inflammation …, 2024 - Taylor & Francis
Background There is no predictive tool developed for pneumonia-associated acute
respiratory distress syndrome (ARDS) specifically so far, and the clinical risk classification of …

Phenotyping refractory cardiogenic shock patients receiving venous-arterial extracorporeal membrane oxygenation with machine learning algorithms

S Wang, L Wang, Z Du, F Yang, X Hao, X Wang… - medRxiv, 2023 - medrxiv.org
Background Refractory cardiogenic shock (CS) patients receiving venous-arterial
extracorporeal membrane oxygenation (VA-ECMO) have a wide range of mortality, machine …