Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …

The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the
integrity of the skeleton through the balanced activities of its constituent cell types. These are …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Abstract Osteopetrosis (" marble bone disease") is a descriptive term that refers to a group of
rare, heritable disorders of the skeleton characterized by increased bone density on …

The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming
osteoblasts. These two cell types are fundamentally different in terms of progenitor cells …

Bone metastases are frequently the final fate of breast and prostate cancer patients.
According to the definition of metastasis as an incurable disease, to date there are no …

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone
erosions, both highlighting the immense reciprocal relationship between the immune and …

Paget's disease of bone (PDB) is a common disorder with a strong genetic component
characterized by focal increases in bone turnover, which in some cases is caused by …

Abstract Purpose of Review The term osteopetrosis refers to a group of rare skeletal
diseases sharing the hallmark of a generalized increase in bone density owing to a defect in …

Functional, biochemical and genetic studies have over the past decade identified many
causative genes in the osteoclast diseases osteopetrosis and Paget's disease of bone …