Polygenic adaptation: a unifying framework to understand positive selection

N Barghi, J Hermisson, C Schlötterer - Nature Reviews Genetics, 2020 - nature.com
Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

[HTML][HTML] The influence of evolutionary history on human health and disease

ML Benton, A Abraham, AL LaBella, P Abbot… - Nature Reviews …, 2021 - nature.com
Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

The long‐standing significance of genetic diversity in conservation

JA DeWoody, AM Harder, S Mathur… - Molecular …, 2021 - Wiley Online Library
Since allozymes were first used to assess genetic diversity in the 1960s and 1970s,
biologists have attempted to characterize gene pools and conserve the diversity observed in …

From variant to function in human disease genetics

T Lappalainen, DG MacArthur - Science, 2021 - science.org
Over the next decade, the primary challenge in human genetics will be to understand the
biological mechanisms by which genetic variants influence phenotypes, including disease …

Variable prediction accuracy of polygenic scores within an ancestry group

H Mostafavi, A Harpak, I Agarwal, D Conley… - elife, 2020 - elifesciences.org
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Genomic insights into population history and biological adaptation in Oceania

J Choin, J Mendoza-Revilla, LR Arauna… - Nature, 2021 - nature.com
The Pacific region is of major importance for addressing questions regarding human
dispersals, interactions with archaic hominins and natural selection processes. However, the …

[HTML][HTML] Features and applications of haplotypes in crop breeding

JA Bhat, D Yu, A Bohra, SA Ganie… - Communications …, 2021 - nature.com
Climate change with altered pest-disease dynamics and rising abiotic stresses threatens
resource-constrained agricultural production systems worldwide. Genomics-assisted …

Trade-offs (and constraints) in organismal biology

T Garland Jr, CJ Downs… - … and Biochemical Zoology, 2022 - journals.uchicago.edu
Trade-offs and constraints are inherent to life, and studies of these phenomena play a
central role in both organismal and evolutionary biology. Trade-offs can be defined …

Threespine stickleback: a model system for evolutionary genomics

K Reid, MA Bell, KR Veeramah - Annual Review of Genomics …, 2021 - annualreviews.org
The repeated adaptation of oceanic threespine sticklebacks to fresh water has made it a
premier organism to study parallel evolution. These small fish have multiple distinct …

Rethinking the fast-slow continuum of individual differences

M Del Giudice - Evolution and Human Behavior, 2020 - Elsevier
The idea that individual differences in behavior and physiology can be partly understood by
linking them to a fast-slow continuum of life history strategies has become popular in the …