[HTML][HTML] A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …

RE Kast, JA Boockvar, A Brüning, F Cappello… - Oncotarget, 2013 - ncbi.nlm.nih.gov
To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …

Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases

W Bild, A Vasincu, RN Rusu, DC Ababei, AB Stana… - Biomolecules, 2022 - mdpi.com
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …

Dengzhan Shengmai capsule attenuates cardiac fibrosis in post-myocardial infarction rats by regulating LTBP2 and TGF-β1/Smad3 pathway

M Wang, M Wang, J Zhao, H Xu, Y Xi, H Yang - Phytomedicine, 2023 - Elsevier
Background Cardiac fibrosis contributes to myocardial remodeling after myocardial
infarction (MI), which may facilitate the progression to end-stage heart failure. Dengzhan …

Formulation, characterisation and evaluation of the antihypertensive peptides, isoleucine-proline-proline and leucine-lysine-proline in chitosan nanoparticles coated …

M Khalid Danish, JP Gleeson, DJ Brayden… - International journal of …, 2022 - mdpi.com
Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived
tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat …

Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases

MF Rasool, S Ali, S Khalid, R Khalid, A Majeed… - Scientific Reports, 2021 - nature.com
The advancement in the processing speeds of computing machines has facilitated the
development of complex physiologically based pharmacokinetic (PBPK) models. These …

Oral adverse drug reactions to cardiovascular drugs

LA Torpet, C Kragelund, J Reibel… - Critical reviews in oral …, 2004 - journals.sagepub.com
A great many cardiovascular drugs (CVDs) have the potential to induce adverse reactions in
the mouth. The prevalence of such reactions is not known, however, since many are …

Captopril prevents experimental autoimmune myocarditis

LM Godsel, JS Leon, K Wang, JL Fornek… - The Journal of …, 2003 - journals.aai.org
Captopril, an angiotensin-converting enzyme inhibitor, is widely used in the treatment of a
variety of cardiomyopathies, but its effect on autoimmune myocarditis has not been …

Antibacterial properties of snake venom components

A Bocian, KK Hus - Chemical Papers, 2020 - Springer
An increasing problem in the field of health protection is the emergence of drug-resistant
and multi-drug-resistant bacterial strains. They cause a number of infections, including …

Renin‐Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension

K Tsuda - International journal of hypertension, 2012 - Wiley Online Library
Many Studies suggest that changes in sympathetic nerve activity in the central nervous
system might have a crucial role in blood pressure control. The present paper discusses …

Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis

TJ Bahk, MD Daniels, JS Leon, K Wang… - International journal of …, 2008 - Elsevier
The angiotensin converting enzyme inhibitor captopril prevents myosin-induced
experimental autoimmune myocarditis. Captopril inhibits production of angiotensin II and …