Bicuspid aortic valve is the most common congenital heart disease and exposes patients to
an increased risk of aortic dilation and dissection. Aortic dilation is a slow, silent process …

Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …

Aims Patients with bicuspid aortic valve (BAV) and aortic regurgitation have higher rate of
aortic complications compared with patients with BAV and stenosis, as well as BAV without …

BACKGROUND: An abnormal accumulation of immune cells and a disrupted lipoprotein
metabolism has previously been described as part of the pathogenesis of ascending aortic …

Objective Aortic dilatation concurrent with aortic valve disease is a common condition.
However, the incidence of aortic dissection after aortic valve replacement for tricuspid aortic …

Bicuspid Aortic Valves (BAV) are associated with an increased incidence of thoracic aortic
aneurysms (TAA). TAA are a common aortic pathology characterized by enlargement of the …

Both relevant aortic valve stenosis (AS) and aortic valve insufficiency significantly contribute
to structural changes in the ascending aorta (AA) and thus to its dilatation. In patients with …

Introduction Thoracic ascending aortic (TAA) aneurysms are an important cause of disability
and death and require early detection for effective management. Currently, there is a paucity …

Background Aortic complications are more likely to occur in patients with ascending aortic
aneurysms and concomitant aortic regurgitation (AR). AR may have a negative influence on …

Being born with a bicuspid aortic valve (BAV) is a significant risk factor for developing an
ascending aortic aneurysm (AscAA). Research has uncovered different mechanisms …